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Electro spinning has been
known since the early 1930’s. It has been used for manufacturing of
non-woven fabrics for the textile industry, like fleece fabrics, and for
medical use like wound dressing and vascular grafts. Corporations like
Imperial Chemical Industries, Bayer Chemical, General Motors, and
Ethicon hold all expired patents within electro spinning.
During the 1990’s, thanks
to advancements in tissue engineering, the refinement of electro
spinning into “nano electro spinning” and fibers in nano sizes began to
resurface. Typical fiber diameters produced by these methods range from
5 to 1000 nm; thereby adding an extremely high surface area to a
polymeric surface but more importantly giving the opportunity to combine
unmixable polymers and drug cocktails into “semi-homogeneous” matrices
with extreme volume containments.
Nano
spinning combines the process of using a high electric force generated
between capillary tips dispensing a polar polymer solution drawn towards
the other pole, the target. The fiber diameter and the spun matrix
porosity can be controlled by regulating the voltage, solution and
solvent composition together with humidity, temperature and pressure in
the environment of the process.
Cardio Capacity’s knowledge in nano
spinning has been established since 2000 by working together with the
University of Akron Ohio US with whom we have fathered products and
patents for its use in the human vascular system making the base for the
business of Millimed A/S, Denmark. |
